FGH31
FGH31 (Compound 24) is a potent, selective, GRK2 dependency dopamine D4 agonist, with the Ki of 1.6 nM. FGH31 partial activates β- arrestin[1].
Product Specifications
UNSPSC
12352005
Target
Arrestin; Dopamine Receptor; G Protein-coupled Receptor Kinase (GRK)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fgh31.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCN1CCN(C2=CC=CC=C2OC)CC1)NC3=CC=CC=C3C4=CC=C(C5=CC=CC=C5)C=C4
Molecular Formula
C33H36N4O2
Molecular Weight
520.66
References & Citations
[1]Graßl F, et al. Exploring Structural Determinants of Bias among D4 Subtype-Selective Dopamine Receptor Agonists. J Med Chem. 2023;66 (14) :9710-9730. doi:10.1021/acs.jmedchem.3c00537
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D4 Receptor; GRK2
Curated Selection
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