HAChE-IN-4
HAChE-IN-4 (Compd 5d) is a potent, blood-brain barrier-permeable hAChE inhibitor with IC50 of 0.25 μM. hAChE-IN-4 can be used in Alzheimer's disease research[1].
Product Specifications
CAS Number
[2983723-58-4]
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(Cl)C=C1)COC2=CC3=C(C=C2)C(C4=CC=C(Cl)C(Cl)=C4)C5=C(N)C6=C(N=C5O3)CCCC6
Molecular Formula
C30H23Cl3N2O3
Molecular Weight
565.87
References & Citations
[1]Salma Fares, et al. Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Synthesis, Biological Evaluation, and Molecular Modeling Study. ACS Omega. 2023 Jul 12;8 (29) :26012-26034.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155086/hAChE-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155086/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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