JM6

JM6 is a weak kynurenine 3-monooxygenase (KMO) inhibitor with an IC50 of 19.85 μM for mouse KMO. JM6 can be used for Alzheimer's diseases research[1].

Product Specifications

CAS Number

[1008119-83-2]

UNSPSC

12352005

Hazard Statement

H301

Target

KMO

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jm6.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(OC)C(OC)=C1)(NC2=NC(C3=CC=CC([N+]([O-])=O)=C3)=C(CN4CCCCC4)S2)=O

Molecular Formula

C23H26N4O6S2

Molecular Weight

518.61

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Maria G Beconi, et al. Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug Metab Dispos. 2012 Dec;40 (12) :2297-306.