PTD10
Product Specifications
UNSPSC Description
PTD10 is a highly potent PROTAC BTK degrader (DC50: 0.5 nM, KD: 2.28 nM). PTD10 degrades BTK in Ramos and JeKo-1 cells with DC50s of 0.5 and 0.6 nM respectively. PTD10 inhibits cell growth, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 can be used for research of B-cell dysregulation[1].
Target Antigen
Btk; PROTACs
Type
Reference compound
Related Pathways
PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptd10.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C=C(C=C1NC2=NC=C(N3CCN(C[C@@H]3C)C(CNC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)C=C2)C7=CC=NC(N8CCN9C(C8=O)=CC%10=C9CC(C)(C%10)C)=C7CO)C
Molecular Weight
922.00
References & Citations
[1]Li YQ, et, al. Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy. J Med Chem. 2023 Jun 8;66(11):7454-7474.|[2]Li YQ, et al. Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy. J Med Chem. 2023 Jun 8;66(11):7454-7474.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154860/PTD10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154860/
Clinical Information
No Development Reported
CAS Number
2642231-19-2
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