5-Me-3’-dU-2’-phosphoramidite
Product Specifications
UNSPSC Description
5-Me-3’-dU-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-me-3-du-2-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C)=C1)NC(N1[C@@H]2O[C@H](COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C[C@H]2OP(OCCC#N)N(C(C)C)C(C)C)=O
Molecular Weight
744.81
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154599/5-Me-3-dU-2-phosphoramidite-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154599/
Clinical Information
No Development Reported
CAS Number
142103-12-6
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