DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite
Product Specifications
UNSPSC Description
DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dmtr-tna-g-o6-conph2-n2ac-amidite.html
Solubility
10 mM in DMSO
Smiles
CC(C)N(C(C)C)P(O[C@@H]1[C@@H](OC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)CO[C@H]1N(C=N5)C6=C5C(OC(N(C7=CC=CC=C7)C8=CC=CC=C8)=O)=NC(NC(C)=O)=N6)OCCC#N
Molecular Weight
993.05
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154592/DMTr-TNA-G-O6-CONPh2-N2Ac-amidite-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154592/
Clinical Information
No Development Reported
CAS Number
325683-97-4
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