FdUMP (triethylammonium)

FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU) . 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

Product Specifications

CAS Number

[134-46-3]

Product Name Alternative

2’-Deoxy-5-Fluorouridine 5’-phosphate (triethylammonium)

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog; Thymidylate Synthase

Type

Oligonucleotides

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-deoxy-5-fluorouridine-5-phosphate-triethylammonium.html

Purity

99.96

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O[C@H]1C[C@H](N(C(N2)=O)C=C(F)C2=O)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC

Molecular Formula

C21H42FN4O8P

Molecular Weight

528.55

References & Citations

[1]Ghoshal K, Jacob ST. An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997;53 (11) :1569-1575.