N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite
N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n2-ibu-5-o-dmtr-2-o-propargylguanosine-3-ced-phosphoramidite.html
Solubility
10 mM in DMSO
Smiles
C#CCO[C@@H]1[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4)O[C@H]1N5C=NC6=C5N=C(NC(C(C)C)=O)NC6=O
Molecular Formula
C47H56N7O9P
Molecular Weight
893.96
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154351/N2-iBu-5-O-DMTr-2-O-propargylguanosine-3-CED-phosphoramidite-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154351/
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
CAS Number
[171486-61-6]
Available Sizes
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MED27 (Mediator of RNA Polymerase II Transcription Subunit 27, Cofactor Required for Sp1 Transcriptional Activation Subunit 8, CRSP Complex Subunit 8, Mediator Complex Subunit 27, P37 TRAP/SMCC/PC2 Subunit, Transcriptional Coactivator CRSP34, MED27, CRSP3
MED27 (Mediator of RNA Polymerase II Transcription Subunit 27, Cofactor Required for Sp1 Transcriptional Activation Subunit 8, CRSP Complex Subunit 8, Mediator Complex Subunit 27, P37 TRAP/SMCC/PC2 Subunit, Transcriptional Coactivator CRSP34, MED27, CRSP3
