CT1113
CT1113 is a potent USP28 and USP25 inhibitor. CT1113 decreases the MYC level in vivo, exhibits anti-tumor activity in mouse pancreatic cancer CDX model[1].
Product Specifications
CAS Number
[2523435-18-7]
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ct1113.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC1=C(C(N[C@@H]2CC3=CC=C(N4CC5NC(CC5)C4)C=C3OC2)=O)SC6=NC(C)=CC=C16
Molecular Formula
C25H29N5O2S
Molecular Weight
463.60
References & Citations
[1]Peng J, et al. Identification of a class of potent USP25/28 inhibitors with broad-spectrum anti-cancer activity. Signal Transduct Target Ther. 2022 Dec 8;7 (1) :393.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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