AST 7062601
AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration[1].
Product Specifications
CAS Number
[675197-89-4]
Product Name Alternative
AST070
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Anion Exchangers
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ast-7062601.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C(NC2=C1C=CC=C2)SCC(NC3=CC=C4OCCOC4=C3)=O
Molecular Formula
C18H15N3O4S
Molecular Weight
369.39
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Vergnes L, et al. Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. J Biol Chem. 2020 Oct 30;295 (44) :15054-15069.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153812/AST-7062601-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153812/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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