CC-3060

CC-3060 is a Cereblon modulator that promotes ZBTB16 degradation. CC-3060 degrades ZBTB16 with a DC50 of 0.47 nM in HT-1080 cells. CC-3060 targets ZBTB16 for degradation by primarily engaging distinct structural degrons on different zinc finger domains[1].

Product Specifications

CAS Number

[444288-86-2]

UNSPSC

12352005

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cc-3060.html

Purity

99.7

Solubility

DMSO : 40 mg/mL (ultrasonic; warming)

Smiles

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC4=CC5=C(C=CC=C5)O4)=CC=C3)=O)=O

Molecular Formula

C22H17N3O5

Molecular Weight

403.39

References & Citations

[1]Matyskiela ME, et al. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS Chem Biol. 2020 Dec 18;15 (12) :3149-3158.