Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Fmoc-L-Asn (EDA-N3) -OH

Fmoc-L-Asn (EDA-N3) -OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2616562-74-2]

UNSPSC

12352005

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fmoc-l-asn-eda-n3-oh.html

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCNC(C[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O

Molecular Formula

C21H21N5O5

Molecular Weight

423.42

References & Citations

[1]Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14 (8) :779-789.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human Ornithine decarboxylase,ODC1 ELISA KIT
JOT-EK0845Hu 96 wells

Human Ornithine decarboxylase,ODC1 ELISA KIT

Sign In for Pricing
View Details
Anti-CD52 (ALLO-647) Biosimilar (Monoclonal, IgG)
A135929 100 µL

Anti-CD52 (ALLO-647) Biosimilar (Monoclonal, IgG)

Sign In for Pricing
View Details
Lentiviral human TMEM69 shRNA (UAS) - Lentiviral human TMEM69 shRNA (UAS, RFP) (100)
GTR15329055 1 Vial

Lentiviral human TMEM69 shRNA (UAS) - Lentiviral human TMEM69 shRNA (UAS, RFP) (100)

Sign In for Pricing
View Details
pOTB7-NUS1 Plasmid
PVT26208 2 µg

pOTB7-NUS1 Plasmid

Sign In for Pricing
View Details
REST Human qPCR Template Standard (NM_005612)
HK209726 1 Kit

REST Human qPCR Template Standard (NM_005612)

Sign In for Pricing
View Details
SLAMF1 (NM_003037) Human Tagged Lenti ORF Clone
RC223343L4 10 µg

SLAMF1 (NM_003037) Human Tagged Lenti ORF Clone

Sign In for Pricing
View Details