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N3-L-Cit-OH

N3-L-Cit-OH is a click chemistry reagent containing an azide group. N3-L-Cit-OH can be used to construct peptidomimetic ADC linkers using Click-chemistry[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1799421-66-1]

UNSPSC

12352211

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n3-l-cit-oh.html

Solubility

10 mM in DMSO

Smiles

NC(NCCC[C@@H](C(O)=O)N=[N+]=[N-])=O

Molecular Formula

C6H11N5O3

Molecular Weight

201.18

References & Citations

[1]Eigenbrot C, et al. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. J Med Chem. 2018 Feb 8;61 (3) :989-1000.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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