N3-L-Cit-OH
Product Specifications
UNSPSC Description
N3-L-Cit-OH is a click chemistry reagent containing an azide group. N3-L-Cit-OH can be used to construct peptidomimetic ADC linkers using Click-chemistry[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Target Antigen
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n3-l-cit-oh.html
Solubility
10 mM in DMSO
Smiles
NC(NCCC[C@@H](C(O)=O)N=[N+]=[N-])=O
Molecular Weight
201.18
References & Citations
[1]Eigenbrot C, et al. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. J Med Chem. 2018 Feb 8;61(3):989-1000.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151709/N3-L-Cit-OH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151709/
Clinical Information
No Development Reported
CAS Number
1799421-66-1
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