6-Azidohexanoyl-Val-Cit-PAB

6-Azidohexanoyl-Val-Cit-PAB is a click chemistry reagent that can be used to synthesis vaccine[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1613321-02-0]

UNSPSC

12352005

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6-azidohexanoyl-val-cit-pab.html

Solubility

10 mM in DMSO

Smiles

O=[N+]([O-])C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN=[N+]=[N-])=O)=O)=O)=O

Molecular Formula

C31H41N9O9

Molecular Weight

683.71

References & Citations

[1]Anderson RJ, Painter GF, et al. NKT cell-dependent glycolipid-peptide vaccines with potent anti-tumour activity. Chem Sci. 2015 Sep 1;6 (9) :5120-5127.