(S)-Trichostatin A
Product Specifications
UNSPSC Description
(S)-Trichostatin A ((S)-TSA) is a HDAC6-selective inhibitor with IC50s of 9.88 nM and 11.1 nM for Zebrafish HDAC6 and Human HDAC6, respectively. (S)-Trichostatin A weakly inhibits other human HDACs[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-trichostatin-a.html
Solubility
10 mM in DMSO
Smiles
ONC(/C=C/C(C)=C/[C@H](C)C(C1=CC=C(C=C1)N(C)C)=O)=O
Molecular Weight
302.37
References & Citations
[1]Yasuyuki Miyake, et al. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol. 2016 Sep;12(9):748-54.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15144B/S-Trichostatin-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15144B/
Clinical Information
No Development Reported
CAS Number
122292-85-7
Curated Selection
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