Nrf2/HO-1 activator 1

Nrf2/HO-1 activator 1 (Compound 24) is a potent Nrf2/HO-1 activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research[1].

Product Specifications

CAS Number

[2883506-60-1]

UNSPSC

12352005

Target

Akt; ERK; JNK; Keap1-Nrf2; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nrf2-ho-1-activator-1.html

Solubility

10 mM in DMSO

Smiles

O=C1C(C2=CC=C(OC)C=C2)=COC3=C1C4=C(C=CC(C)(C)O4)C(O)=C3

Molecular Formula

C21H18O5

Molecular Weight

350.36

References & Citations

[1]Qili Lu, et al. Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/HO-1 signaling. Eur J Med Chem. 2022 Nov 15;242:114692.