ALK5-IN-31
Product Specifications
UNSPSC Description
ALK5-IN-31 (compound Ex-08) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-31 has the potential to inhibit growth of tumour in vivo. ALK5-IN-31 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].
Target Antigen
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-31.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C(F)=C4)=NC=C3)C=NN=C12
Molecular Weight
430.48
References & Citations
[1]Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151281/ALK5-IN-31-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151281/
Clinical Information
No Development Reported
CAS Number
2785430-87-5
Curated Selection
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