C-Met-IN-13

C-Met-IN-13 is a potent c-Met inhibitor with an IC50 value of 2.43 nM. c-Met-IN-13 shows excellent cytotoxicity for cancer cells. c-Met-IN-13 shows antiproliferative activity in a concentration- and time- dependent manner. c-Met-IN-13 has the potential for the research of cancer[1].

Product Specifications

CAS Number

[2377724-93-9]

UNSPSC

12352005

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c-met-in-13.html

Solubility

10 mM in DMSO

Smiles

O=C(OC(C(C)(C)C)C(NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C(F)=C1)=O)C4=CC=C(F)C=C4

Molecular Formula

C30H28F2N2O6

Molecular Weight

550.55

References & Citations

[1]Nan X, et al. Structure-based discovery of novel 4- (2-fluorophenoxy) quinoline derivatives as c-Met inhibitors using isocyanide-involved multicomponent reactions. Eur J Med Chem. 2020 May 1;193:112241.