INOs-IN-3

INOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 μM) . iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research[1].

Product Specifications

CAS Number

[2241674-94-0]

UNSPSC

12352005

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/inos-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2=CC=CC(OS(=O)(C3=CC=CC4=C(N(C)C)C=CC=C43)=O)=C2N1CCC5=CC=CC=C5

Molecular Formula

C27H24N2O5S

Molecular Weight

488.55

References & Citations

[1]Li Tang, et al. Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI) . Bioorg Med Chem. 2020 Nov 1;28 (21) :115733.