BMV109
BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases. BMV109 can be exploited for tumor imaging[1][2].
Product Specifications
CAS Number
[1458731-58-2]
UNSPSC
12171500
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bmv109.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=C(C=CC=C1)C(C2=CC=C(N3C4=CC=C(S(=O)([O-])=O)C=C4CC3)C=C2O5)=C(C=C/6)C5=CC6=[N+]7C8=CC=C(S(=O)(O)=O)C=C8CC/7)(N9CCC(CC9)C(NCCNC(C%10=C(C(F)=C(C(F)=C%10F)OCC([C@H](CCCCNC(CCCCCN%11C%12=CC=C(S(=O)(O)=O)C=C%12C(C)(/C%11=C/C=C/C=C/C%13=[N+](C%14=CC=C(S(=O)([O-])=O)C=C%14C%13(C)C)CC)C)=O)NC([C@@H](NC(OCC%15=CC=CC=C%15)=O)CC%16=CC=CC=C%16)=O)=O)F)=O)=O)=O
Molecular Formula
C107H108F4N10O23S5
Molecular Weight
2138.37
References & Citations
[1]Martijn Verdoes, et al. Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc. 2013 Oct 2;135 (39) :14726-30. |[2]Steven Sensarn, et al. A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer. Mol Imaging Biol. 2016 Dec;18 (6) :820-829.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149931/BMV109-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149931/
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Curated Selection
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