Phosphodiesterase-IN-1

Phosphodiesterase-IN-1 (Compound 7) is a phosphodiesterase (PDE) inhibitor with anti-Plasmodium activity. Phosphodiesterase-IN-1 has antiproliferative activity against P. falciparum (strain 3D7) with an IC50 value of 0.64 μM[1].

Product Specifications

CAS Number

[521297-42-7]

UNSPSC

12352005

Target

Parasite; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/phosphodiesterase-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C1N=C(CC2=CC=C(C=C2)F)NC3=C1NN=C3C(C)C

Molecular Formula

C15H15FN4O

Molecular Weight

286.30

References & Citations

[1]Howard BL, et al. Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites. ACS Chem Biol. 2015 Apr 17;10 (4) :1145-54.