ATP Synthesis-IN-3
Product Specifications
UNSPSC Description
ATP Synthesis-IN-3 (compound 31) is an ATP hydrolysis inhibitor with protective effects during myocardial ischemia. ATP Synthesis-IN-3 can increase the ATP content of ischemic cardiomyocytes, increase the phosphorylation of PKA and phospholamban, and inhibit ischemia-induced apoptosis[1].
Target Antigen
ATP Synthase; PKA
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Stem Cell/Wnt;TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/atp-synthesis-in-3.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=CC=C(NC3=NC(N4CCOCC4)=C5C(C(C6=CC=CC=C6)=NN5CC7=CC=C(C=C7)OC)=C3)C=C2)CC1
Molecular Weight
589.73
References & Citations
[1]Nikolaou PE et al. Hydrolytic Activity of Mitochondrial F1FO-ATP Synthase as a Target for Myocardial Ischemia-Reperfusion Injury: Discovery and In Vitro and In Vivo Evaluation of Novel Inhibitors. J Med Chem. 2023 Nov 23;66(22):15115-15140.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149736/ATP-Synthesis-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149736/
Clinical Information
No Development Reported
CAS Number
3032416-36-4
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