Ferroptosis-IN-4

Ferroptosis-IN-4 (compound 6k) is a ferroptosis inhibitor with EC50 value of 20 μM. Ferroptosis-IN-4 has no obvious cytotoxicity. Ferroptosis-IN-4 has a protective effect in glycerol-induced RM-AKI mice with alleviating kidney dysfunction[1].

Product Specifications

CAS Number

[2798922-35-5]

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ferroptosis-in-4.html

Solubility

10 mM in DMSO

Smiles

CN(CCN(C)C)C1=CC=C(N2C(C)=C(O)C(C=C2)=O)C=C1.Cl

Molecular Formula

C17H24ClN3O2

Molecular Weight

337.84

References & Citations

[1]Jie Cen, et al. Synthesis and structure-activity optimization of hydroxypyridinones against rhabdomyolysis-induced acute kidney injury. Eur J Med Chem. 2023.