ICMT-IN-35
ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM) . ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines[1].
Product Specifications
UNSPSC
12352005
Target
ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/icmt-in-35.html
Solubility
10 mM in DMSO
Smiles
C/C(CCN(N=N1)C=C1CCC(C=C2)=CC=C2C3=CC=CC=C3)=C/SCCC(OC)=O
Molecular Formula
C25H29N3O2S
Molecular Weight
435.58
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149709/ICMT-IN-35-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149709/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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