Ferroptosis-IN-3

Ferroptosis-IN-3 (Compound 25) is a ferroptosis inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC50: 8.6 nM in HT-1080 cells) . Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC50: 3.94 and 6.3 μM respectively) . Ferroptosis-IN-3 decreases lipid peroxidation[1].

Product Specifications

CAS Number

[3017222-33-9]

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ferroptosis-in-3.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C2=CC=C(O)C=C2)NN=C1C3=CC=C(Cl)C=C3

Molecular Formula

C15H11ClN2O2

Molecular Weight

286.71

References & Citations

[1]Ying Danzhi, et al. Discovery of 4-hydroxyl pyrazole derivatives as potent ferroptosis inhibitors. European Journal of Medicinal Chemistry Available online 4 November 2023, 115913.