CDK9-IN-29

CDK9-IN-29 (compound Z11) is a potent CDK9 inhibitor (IC50 = 3.20 nM) with good kinase selectivity. CDK9-IN-29 inhibits cell proliferation and induces apoptosis[1].

Product Specifications

CAS Number

[2737262-24-5]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk9-in-29.html

Solubility

10 mM in DMSO

Smiles

FC1=C(C=C(C=C1)C2=C(C=NC(N3)=N2)F)OCCCCCCOC4=CC3=CC=C4C(NCCN5CCOCC5)=O

Molecular Formula

C29H33F2N5O4

Molecular Weight

553.60

References & Citations

[1]Tizhi Wu, et al. Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2023.