PPM-3

PPM-3 is a potent and selective PROTAC ERK5 degrader, with an IC50 of 62.4 nM. PPM-3 did not influence tumor cell growth directly. PPM-3 influences tumor development by affecting the differentiation of macrophages[1].

Product Specifications

CAS Number

[3032388-42-1]

UNSPSC

12352005

Target

ERK; PROTACs

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; PROTAC; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ppm-3.html

Purity

98.2

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1N(C)C2=NC(NC3=CC=C(C=C3OC)N4CCN(CC4)CCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(N[C@H](C6=CC=C(C=C6)C7=C(N=CS7)C)C)=O)O)=O)=O)=NC=C28)N8C

Molecular Formula

C54H69N11O6S

Molecular Weight

1000.26

References & Citations

[1]Pan P, et al. Design, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5. J Med Chem. 2023 Oct 12;66 (19) :13568-13586.