VEGFR-2-IN-33

VEGFR-2-IN-33 (Compound 4d) is a VEGFR inhibitor (IC50: 61.04 nM) . VEGFR-2-IN-33 inhibits HepG2 cell proliferation with an IC50 of 4.31 nM. VEGFR-2-IN-33 can be used for research of hepatocellular carcinoma (HCC) [1].

Product Specifications

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-33.html

Solubility

10 mM in DMSO

Smiles

O=S(C(C=C1)=CC=C1N=C2SC3=NC4=CC=CC=C4N=C3N2)(NC5=CC=CC=N5)=O

Molecular Formula

C20H14N6O2S2

Molecular Weight

434.49

References & Citations

[1]El-Hazek RMM, et al. Novel VEGFR2 inhibitors with thiazoloquinoxaline scaffold targeting hepatocellular carcinoma with lower cardiotoxic impact. Sci Rep. 2023 Aug 25;13 (1) :13907.