VEGFR-2-IN-33
VEGFR-2-IN-33 (Compound 4d) is a VEGFR inhibitor (IC50: 61.04 nM) . VEGFR-2-IN-33 inhibits HepG2 cell proliferation with an IC50 of 4.31 nM. VEGFR-2-IN-33 can be used for research of hepatocellular carcinoma (HCC) [1].
Product Specifications
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-33.html
Solubility
10 mM in DMSO
Smiles
O=S(C(C=C1)=CC=C1N=C2SC3=NC4=CC=CC=C4N=C3N2)(NC5=CC=CC=N5)=O
Molecular Formula
C20H14N6O2S2
Molecular Weight
434.49
References & Citations
[1]El-Hazek RMM, et al. Novel VEGFR2 inhibitors with thiazoloquinoxaline scaffold targeting hepatocellular carcinoma with lower cardiotoxic impact. Sci Rep. 2023 Aug 25;13 (1) :13907.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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