HCAIX/VII-IN-1

HCAIX/VII-IN-1 is a selective hCA VII/IX inhibitor. hCAIX/VII-IN-1 inhibit hCAI, hCAII, hCAIV, hCAVII and hCAIX with Ki values of 336.2 nM,185.8 nM, 1055 nM, 35.6 nM and 28.0 nM, respectively. hCAIX/VII-IN-1 can be used for the research of cancer and neurological diseases[1].

Product Specifications

CAS Number

[2990559-21-0]

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hcaix-vii-in-1.html

Solubility

10 mM in DMSO

Smiles

OB1OCC2=CC=C(C=C12)N3N=NC(COC4=CC=C(C=C4)F)=C3

Molecular Formula

C16H13BFN3O3

Molecular Weight

325.10

References & Citations

[1]Nocentini A, et al. 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors: In Silico Design, Synthesis, and X-ray Crystallography. J Med Chem. 2023 Jun 22;66 (12) :8118-8129.