ATM Inhibitor-7
Product Specifications
UNSPSC Description
ATM Inhibitor-7 is a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor with an IC50 value of 1.0 nM. ATM Inhibitor-7 induces Apoptosis and cell cycle arrest at G2/M phase when combinanted with CPT-11 (HY-16562). ATM Inhibitor-7 combines with CPT-11 shows antitumor activity[1].
Target Antigen
Apoptosis; ATM/ATR
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCCOC1=NC=C(C2=CC=C(N=CC3=C4N([C@H](C)C5=CC=CC=C5)N=N3)C4=C2)C=C1
Molecular Weight
452.55
References & Citations
[1]Shiyu Zhang, et al. Discovery of [1,2,3]Triazolo[4,5-c]quinoline Derivatives as a New Class of Ataxia-Telangiectasia Mutated Kinase Inhibitors. ACS Med. Chem. Lett. 2023.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149291/ATM-Inhibitor-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149291/
Clinical Information
No Development Reported
CAS Number
3033712-80-7
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
E1579b 96 Tests
ELISA Kit For Low affinity immunoglobulin gamma Fc region receptor II
Ask
View Details