Nrf2 activator-7
Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.
Product Specifications
CAS Number
[2456295-39-7]
UNSPSC
12352005
Target
Keap1-Nrf2; Quinone Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-7.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)C2=C(C3=C(C(N(S(=O)(C4=CC=C(C=C4)OC)=O)CC(O)=O)=C2)C=CC=C3)N(S(=O)(C5=CC=C(C=C5)OC)=O)CC(O)=O
Molecular Formula
C35H32N2O11S2
Molecular Weight
720.77
References & Citations
[1]Abed DA, et al. Optimization of the C2 substituents on the 1,4-bis (arylsulfonamido) naphthalene-N, N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2023 Apr 5;252:115302.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149244/Nrf2-activator-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149244/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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