MPX-004
Product Specifications
UNSPSC Description
MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC50 of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research[1].
Target Antigen
iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mpx-004.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC=C(CNS(=O)(C2=CC=C(C(Cl)=C2)F)=O)N=C1)NCC3=CN=C(C)S3
Molecular Weight
455.91
References & Citations
[1]Robert A Volkmann, et al. MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS One. 2016 Feb 1;11(2):e0148129.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148939/MPX-004-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148939/
Clinical Information
No Development Reported
CAS Number
1688684-07-2
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