Monarsen (sodium)

Monarsen sodium is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen sodium is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR) .

Product Specifications

Product Name Alternative

EN101 (sodium) ; ODN 7040 (sodium) ; BL 7040 (sodium)

UNSPSC

12352208

Target

Cholinesterase (ChE)

Type

Oligonucleotides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/monarsen-sodium.html

Solubility

10 mM in H2O

Smiles

[Monarsen(sodium)]

References & Citations

[1]Sussman JD, Argov Z, McKee D, Hazum E, Brawer S, Soreq H. Antisense treatment for myasthenia gravis: experience with monarsen. Ann N Y Acad Sci. 2008;1132:283-290. |[2]Evron T, Moyal-Segal LB, Lamm N, Geffen A, Soreq H. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegener Dis. 2005;2 (1) :16-27. |[3]Kehat R, Zemel E, Cuenca N, et al. A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress. Invest Ophthalmol Vis Sci. 2007;48 (3) :1290-1297.