Zorevunersen

Zorevunersen (STK-001) is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav1.1 protein. Zorevunersen is used for the study of Dravet syndrome.

Product Specifications

CAS Number

[2415330-04-8]

Product Name Alternative

STK-001

UNSPSC

12352208

Target

Sodium Channel

Type

Oligonucleotides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/zorevunersen.html

Solubility

10 mM in DMSO

Smiles

[Zorevunersen]

Molecular Formula

C204H263N63O114P20S20

Molecular Weight

7197.2

References & Citations

[1]Wengert ER, Wagley PK, Strohm SM, et al. Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res. 2022;1775:147743. |[2]Bialer M, Johannessen SI, Koepp MJ, et al. Progress report on new antiepileptic drugs: A summary of the Sixteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVI) : II. Drugs in more advanced clinical development. Epilepsia. 2022;63 (11) :2883-2910.