Ganglioside GM2

Ganglioside GM2 is a human tumor antigen predominantly found in human tumor cells and fetal brain tissue. As a sialylated glycosphingolipid, Ganglioside GM2 is involved in processes such as cell signaling, adhesion, and motility. Ganglioside GM2 abnormal expression and accumulation are associated with tumors and neurodegenerative disorders. Ganglioside GM2 promotes tumor cell migration and invasion by directly binding to the integrin β1 receptor, activating the FAK/Src/Erk-MAPK signaling pathway, and inducing actin cytoskeleton remodeling[1][2][3].

Product Specifications

CAS Number

[127663-77-8]

UNSPSC

12352005

Target

Endogenous Metabolite; ERK; FAK; Integrin; p38 MAPK; Src

Type

Natural Products

Related Pathways

Cytoskeleton; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ganglioside-gm2.html

Purity

98.0

Smiles

OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2O)O[C@@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC)=O)CO)CO)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)=O

Molecular Formula

C67H121N3O26

Molecular Weight

1384.68

References & Citations

[1]Tai T, et al. Ganglioside GM2 as a human tumor antigen (OFA-I-1) . Proc Natl Acad Sci U S A. 1983 Sep;80 (17) :5392-6.|[2]Kundu M, et al. Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway. Biochim Biophys Acta. 2016 Jul;1863 (7 Pt A) :1472-89.|[3]Sandhoff K, et al. Gangliosides and gangliosidoses: principles of molecular and metabolic pathogenesis. J Neurosci. 2013 Jun 19;33 (25) :10195-208.