GlcN-6-P Synthase-IN-1

GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform[1].

Product Specifications

CAS Number

[2415311-87-2]

UNSPSC

12352005

Target

Bacterial; Cytochrome P450; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/glcn-6-p-synthase-in-1.html

Solubility

10 mM in DMSO

Smiles

N=C(N/N=C(C)/C1=C(C)N=C(N/N=C/C2=CC=C(C3=CC=CC=C3)C=C2)S1)N

Molecular Formula

C20H21N7S

Molecular Weight

391.49

References & Citations

[1]Omar AM, et al. The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase. Bioorg Chem. 2020 Jun;99:103781.