GlcN-6-P Synthase-IN-1
Product Specifications
UNSPSC Description
GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform[1].
Target Antigen
Bacterial; Cytochrome P450; Fungal
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/glcn-6-p-synthase-in-1.html
Solubility
10 mM in DMSO
Smiles
C/C(C1=C(C)N=C(N/N=C/C2=CC=C(C3=CC=CC=C3)C=C2)S1)=N\NC(N)=N
Molecular Weight
391.49
References & Citations
[1]Omar AM, et al. The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase. Bioorg Chem. 2020 Jun;99:103781.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147999/GlcN-6-P-Synthase-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147999/
Clinical Information
No Development Reported
CAS Number
2447602-44-8
Curated Selection
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