KDM1/CDK1-IN-1
Product Specifications
UNSPSC Description
KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively[1].
Target Antigen
Apoptosis; Caspase; CDK; Histone Demethylase
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kdm1-cdk1-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(O)N2C(N=C1)=C(C3=NC4=CC=CC=C4S3)C(NC5=CC=CC=C5)=N2)OCC
Molecular Weight
431.47
References & Citations
[1]Husseiny EM. Synthesis, cytotoxicity of some pyrazoles and pyrazolo[1,5-a]pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action. Bioorg Chem. 2020 Sep;102:104053.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147901/KDM1-CDK1-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147901/
Clinical Information
No Development Reported
CAS Number
2938990-92-0
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