BACE1-IN-12
BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH) . BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].
Product Specifications
CAS Number
[2479315-19-8]
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-in-12.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(CN2N=NC(COC3=CC=C(C4=C(NC5CCCCC5)N6C=CC=CC6=N4)C=C3)=C2)C=C1Cl
Molecular Formula
C29H28Cl2N6O
Molecular Weight
547.48
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1
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