GAK inhibitor 2
GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV) [1].
Product Specifications
CAS Number
[2396706-31-1]
UNSPSC
12352005
Target
Antibiotic; Dengue Virus; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gak-inhibitor-2.html
Concentration
10mM
Purity
98.58
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=CC=C(C2=NC3=C(N4C[C@@H](C)O[C@@H](C)C4)SN=C3C=C2)C=C1OC
Molecular Formula
C20H23N3O3S
Molecular Weight
385.48
References & Citations
[1]Martinez-Gualda B, et al. Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase. Bioorg Med Chem. 2020 Jan 1;28 (1) :115188.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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