GAK inhibitor 2
Product Specifications
UNSPSC Description
GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV)[1].
Target Antigen
Antibiotic; Dengue virus; Flavivirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gak-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C2=NC3=C(N4C[C@@H](C)O[C@@H](C)C4)SN=C3C=C2)C=C1OC
Molecular Weight
385.48
References & Citations
[1]Martinez-Gualda B, et al. Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase. Bioorg Med Chem. 2020 Jan 1;28(1):115188.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147761/GAK-inhibitor-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147761/
Clinical Information
No Development Reported
CAS Number
2396706-31-1
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