GAK inhibitor 2

GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV) [1].

Product Specifications

CAS Number

[2396706-31-1]

UNSPSC

12352005

Target

Antibiotic; Dengue Virus; Flavivirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gak-inhibitor-2.html

Concentration

10mM

Purity

98.58

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC=C(C2=NC3=C(N4C[C@@H](C)O[C@@H](C)C4)SN=C3C=C2)C=C1OC

Molecular Formula

C20H23N3O3S

Molecular Weight

385.48

References & Citations

[1]Martinez-Gualda B, et al. Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase. Bioorg Med Chem. 2020 Jan 1;28 (1) :115188.