NS-8

NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1].

Product Specifications

CAS Number

[186033-14-7]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/ns-8.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C2=C(F)C=CC=C2)NC(N)=C1C#N

Molecular Formula

C12H10FN3

Molecular Weight

215.23

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]M Tanaka, et al. A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity. BJU Int. 2003 Dec;92 (9) :1031-6.