ZIKV-IN-1

ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain[1]. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2762166-06-1]

UNSPSC

12352005

Target

Flavivirus; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zikv-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=NC=NC2=C1C(C#CC3=CC(F)=C(C=C3)Br)=CN2[C@@H]4O[C@@H]([C@H]([C@]4(F)C)O)CO

Molecular Formula

C21H18BrF2N3O3

Molecular Weight

478.29

References & Citations

[1]Yao G, et al. Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents. Eur J Med Chem. 2022 Apr 15;234:114275.