ZIKV-IN-1
Product Specifications
UNSPSC Description
ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain[1]. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Flavivirus; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zikv-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=NC=NC2=C1C(C#CC3=CC(F)=C(C=C3)Br)=CN2[C@@H]4O[C@@H]([C@H]([C@]4(F)C)O)CO
Molecular Weight
478.29
References & Citations
[1]Yao G, et al. Design, synthesis, and biological evaluation of novel 2'-methyl-2'-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents. Eur J Med Chem. 2022 Apr 15;234:114275.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146957/ZIKV-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146957/
Clinical Information
No Development Reported
CAS Number
2762166-06-1
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