Antimalarial agent 11

Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].

Product Specifications

CAS Number

[1214454-56-4]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antimalarial-agent-11.html

Solubility

10 mM in DMSO

Smiles

OC(CN1CCC2(CC(O)C3=C(O2)C4=C(C=CC=C4)C=C3)CC1)C5=CC=C(F)C(F)=C5

Molecular Formula

C25H25F2NO3

Molecular Weight

425.47

References & Citations

[1]Iredia D Iyamu, et al. Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity. Bioorg Med Chem. 2022 Mar 1;57:116629.