GLS1 Inhibitor-4
GLS1 Inhibitor-4 (compound 41e) is a potent GLS1 inhibitor with an IC50 of 11.86 nM. GLS1 Inhibitor-4 shows antiproliferative activity, good metabolic stability, robust GLS1 binding affinity. GLS1 Inhibitor-4 blocks the glutamine metabolism and induce the production of ROS. GLS1 Inhibitor-4 induces apoptosis and shows antitumor activity[1].
Product Specifications
CAS Number
[2768599-97-7]
UNSPSC
12352005
Target
Apoptosis; Glutaminase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gls1-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NN=C(S1)N2CCC(CC2)NC3=NN=C(S3)NC(CC4=CC=CC=C4)=O)C5=NC=CN5CC(C=C6)=CC=C6C(F)(F)F
Molecular Formula
C29H27F3N10O2S2
Molecular Weight
668.72
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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