Dexamethasone-d5

Dexamethasone-d5 is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].

Product Specifications

CAS Number

[358731-91-6]

Product Name Alternative

Hexadecadrol-d5; Prednisolone F-d5

UNSPSC

12352211

Hazard Statement

H315, H317, H319, H334, H335

Target

Antibiotic; Autophagy; Bacterial; Complement System; Glucocorticoid Receptor; Mitophagy; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Autophagy; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Infection; Endocrinology; Inflammation/Immunology

Purity

99.23

Solubility

10 mM in DMSO|DMSO : 250mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@](C(C([2H])(O)[2H])=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])CC([2H])([2H])C4=C([2H])C(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O

Molecular Formula

C22H24D5FO5

Molecular Weight

397.49

Precautions

H315, H317, H319, H334, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122 (2) :249-56|[3]LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31 (3) :611-22.|[4]Heidi Ledford. et al. Coronavirus Breakthrough: Dexamethasone Is First Drug Shown to Save Lives. Nature. 2020 Jun 16.|[5]Yun Chen, et al. Glucocorticoids inhibit production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Int J Clin Exp Pathol 2018;11 (7) :3391-3397.|[6]Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541 (1-3) :75-9.|[7]Ballabh P, et al. Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89 (1) :F76-83.|[8]Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127 (4) :1003-11