CDK4/6-IN-12

CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2445205-24-1]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk4-6-in-12.html

Purity

99.76

Solubility

10 mM in DMSO

Smiles

CC1=CN2C3=NC(N)=NC=C3C(C)=C(C2=N1)C#N

Molecular Formula

C12H10N6

Molecular Weight

238.25

References & Citations

[1]Chen Shi, et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239.