CRK12-IN-1
Product Specifications
UNSPSC Description
CRK12-IN-1 is a potent CRK12 inhibitor. CRK12-IN-1 is extremely potent against T.b. brucei and rapidly cytocidal, as well as equally potent against T. congolense and T. vivax (EC50 of 1.3 and 18 nM, respectively)[1].
Target Antigen
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/crk12-in-1.html
Solubility
10 mM in DMSO
Smiles
O=S(N[C@@H]1CC[C@@H](NC2=NC(N)=C(C(C3=C(F)C=CC=C3F)=O)S2)CC1)(CC(C)C)=O
Molecular Weight
472.57
References & Citations
[1]Smith A, et al. Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis [published online ahead of print, 2022 Mar 18]. J Med Chem. 2022;10.1021/acs.jmedchem.1c02104.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145812/CRK12-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145812/
Clinical Information
No Development Reported
CAS Number
1990479-14-5
Curated Selection
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