Reboxetine

Reboxetine is an orally active, potent and selective noradrenaline uptake blocker. Reboxetine can be used for antidepressant research[1].

Product Specifications

CAS Number

[71620-89-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/reboxetine.html

Solubility

10 mM in DMSO

Smiles

CCOC1=CC=CC=C1O[C@@H]([C@@]2([H])CNCCO2)C3=CC=CC=C3

Molecular Formula

C19H23NO3

Molecular Weight

313.39

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Dostert P, et al. Reboxetine prevents the tranylcypromine-induced increase in tyramine levels in rat heart. J Neural Transm Suppl. 1994;41:149-53.|[2]Erik H. F. Wong, Saeeduddin Ahmed, et al. Highly selective norepinephrine reuptake inhibitors and methods of using the same. WO2001001973A2 |[3]Herman BD, Fleishaker JC, Brown MT. Ketoconazole inhibits the clearance of the enantiomers of the antidepressant reboxetine in humans. Clin Pharmacol Ther. 1999 Oct;66 (4) :374-9.