Resolvin D5

Resolvin D5 is a prolytic mediator (SPM) with anti-inflammatory activity derived from oxidized lipids DHA. Resolvin D5 inhibits Th17 cell differentiation and promotes regulatory T cell differentiation, and inhibits CD4+ T cell proliferation. Resolvin D5 attenuates osteoclast differentiation and interferes with osteoclastogenesis. Resolvin D5 also regulates ERK phosphorylation and nuclear translocation of NF-kappaB. Resolvin D5 could be used in rheumatoid arthritis research[1][2].

Product Specifications

CAS Number

[578008-43-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ERK; NF-κB

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/resolvin-d5.html

Concentration

277.40 μM * 50 μL in Ethanol

Purity

98.3

Solubility

10 mM in DMSO

Smiles

CC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O

Molecular Formula

C22H32O4

Molecular Weight

360.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Yamada H, et al. Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis. Sci Rep. 2021 Aug 27;11 (1) :17312.|[2]Chun HW, et al. Resolvin D5, a Lipid Mediator, Inhibits Production of Interleukin-6 and CCL5 Via the ERK-NF-κB Signaling Pathway in Lipopolysaccharide-Stimulated THP-1 Cells. J Microbiol Biotechnol. 2020 Jan 28;30 (1) :85-92.